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- Title
Combination of perindopril/indapamide in secondary prevention of stroke and other vascular events: A combined analysis of ADVANCE, PROGRESS and HYVET trials.
- Authors
Sarkar, Sougat S.
- Abstract
Perindopril/indapamide combination has been shown to reduce cardiovascular risk in different groups of patients. A total of 18,529 patients (9,272 receiving perindopril/indapamide and 9,257 receiving placebo) were included in this meta-analysis involving three large randomized clinical trials-ADVANCE, PROGRESS and HYVET. A non-significant reduction in fatal and non-fatal stroke was seen (Odds ratio 0.73; 95% Confidence Interval 0.49 to 1.09; z=1.52 and p= 0.13). The fixed combination perindopril and indapamide was associated with a significant reduction of vascular death (Odds ratio 0.79; 95% Confidence Interval 0.69 to 0.90; z=3.48 and p=0.0005) and major cardiovascular events (Odds ratio 0.72; 95% Confidence Interval 0.53 to 0.97; z=2.15 and p= 0.03). However, effect on stroke needs further evaluation.
- Subjects
STROKE prevention; INDAPAMIDE; DISEASE progression; CLINICAL trials; META-analysis; CEREBROVASCULAR disease
- Publication
Bangladesh Journal of Pharmacology, 2011, Vol 6, Issue 1, p25
- ISSN
1991-007X
- Publication type
Article
- DOI
10.3329/bjp.v6i1.7920