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- Title
la-Expressing Cells and T Lymphocytes of Different Subsets in Peripheral Nerve Tissue during Experimental Allergic Neuritis in Lewis Rats.
- Authors
Olsson, T.; Holmdahl, R.; Klareskog, L.; Forsum, U.
- Abstract
Inflammatory infiltrates in sciatic nerves during the acute phase of experimental allergic neuritis in the Lewis rat have been characterized with regard to occurrence and distribution of Ia-expressing cells and T-lymphocyte subsets by the help of an immunohistochemical double-staining technique, enabling the simultaneous visualization of T lymphocytes and Ia-expressing non-T cells. Large numbers of Ia-expressing irregular macrophage-like/dendritic cells were seen both within inflammatory infiltrates and within afflicted nervous tissue. Many W3/13-reactive T lymphocytes of both 'helper' and 'suppressor/cytoxic' phenotypes appeared in close contact with these Ia-expressing non-T cells, particularly within the infiltrates. B lymphocytes and plasma cells were relatively few and mainly found close to endoneurial vessels.
- Subjects
T cells; LYMPHOCYTES; LYMPHOID tissue; LABORATORY rats; DENDRITIC cells; IMMUNOHISTOCHEMISTRY
- Publication
Scandinavian Journal of Immunology, 1983, Vol 18, Issue 4, p339
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1983.tb01805.x