We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Safety and efficacy of radioallergosorbent test-based allergen immunotherapy in treatment of perennial allergic rhinitis and asthma
- Authors
Yeoh, Kian Hian; Wang, De Yun; Gordon, Bruce R.
- Abstract
This study was undertaken to demonstrate the safety and efficacy of in vitro, radioallergosorbent test (RAST)-based inhalant allergen immunotherapy.Prospective 22 year single site clinical study, with outcome evaluations of 480 perennial allergic rhinitis patients, including 96 with concomitant asthma.Rhinitis symptom control after 2 years of immunotherapy was excellent in 32.5% of patients, good in 45.6%, and fair in 14.2%. There was no improvement in 7.7%. For patients with asthma, 81% had good or excellent pulmonary symptom improvement, and no patient failed to improve. No severe reactions occurred, but there were 5 limited systemic reactions, or 0.008% of injections, during a 2.5-year mean immunotherapy treatment course.RAST-based immunotherapy is safe and effective for patients with perennial allergic rhinitis, with or without concomitant asthma.This is the first large, multiyear study of safety and efficacy of RAST-based immunotherapy for treatment of perennial allergic rhinitis and asthma. EBM rating: C.
- Subjects
OBSTRUCTIVE lung diseases; ALLERGIC rhinitis; IMMUNOTHERAPY; THERAPEUTICS
- Publication
Otolaryngology-Head & Neck Surgery, 2004, Vol 131, Issue 5, p673
- ISSN
0194-5998
- Publication type
Article
- DOI
10.1016/j.otohns.2004.04.020