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- Title
Elevated circulating tissue factor procoagulant activity, factor VII, and plasminogen activator inhibitor-1 in childhood obesity: evidence of a procoagulant state.
- Authors
Singh, Anamika; Foster, Gary D.; Gunawardana, Jay; McCoy, Tara Alexis; Nguyen, Tina; Vander Veur, Stephanie; Komaroff, Eugene; Rao, Angara Koneti
- Abstract
Childhood obesity is rapidly increasing in prevalence. We compared circulating membrane-bound tissue factor ( FIII, F3) procoagulant activity ( TF- PCA) and plasma markers of coagulation, fibrinolysis and endothelial dysfunction in 21 obese (10·1 ± 1·5 years, mean ± standard deviation) and 22 healthy weight children (9·9 ± 1·6 years), classified by Body Mass Index ( BMI). TF- PCA and factor VII coagulant activity ( FVII: C), plasminogen activator inhibitor ( PAI-1, SERPINE1) and soluble vascular cell adhesion molecule 1 ( sVCAM1) were higher in obese children. BMI correlated positively with TF- PCA, FVII: C, and PAI-1. Childhood obesity is associated with a procoagulant state and endothelial dysfunction. Studies are needed to assess whether weight reduction reverses these abnormalities.
- Subjects
CHILDHOOD obesity; PLASMINOGEN activator inhibitors; FIBRINOLYSIS; ENDOTHELIUM; THROMBOPLASTIN; BODY weight; BLOOD coagulation
- Publication
British Journal of Haematology, 2012, Vol 158, Issue 4, p523
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/j.1365-2141.2012.09160.x