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- Title
Genomic analysis of Non-Splenic Marginal Zone Lymphomas (MZL) indicates similarities between nodal and extranodal MZL and supports their derivation from Memory B-cells.
- Authors
Novak, Urban; Basso, Katia; Pasqualucci, Laura; Dalla-Favera, Riccardo; Bhagat, Govind
- Abstract
Summary Three distinct categories of marginal zone lymphomas (MZLs) are currently recognized, principally based on their site of occurrence. They are thought to represent unique entities, but the relationship of one subtype with another is poorly understood. We investigated 17 non-splenic MZLs (seven nodal, 10 extranodal) by gene expression profiling to distinguish between subtypes and determine their cell of origin. Our findings suggest biological inter-relatedness of these entities despite occurrence at different locations and associations with possibly different aetiologies. Furthermore, the expression profiles of non-splenic MZL were similar to memory B cells.
- Subjects
LYMPHOMAS; GENE expression; B cells; ETIOLOGY of diseases; HODGKIN'S disease; TRANSCRIPTION factors
- Publication
British Journal of Haematology, 2011, Vol 155, Issue 3, p362
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/j.1365-2141.2011.08841.x