We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Two‐stage Regioselective Access to Non‐symmetric 3,5‐Diarylisoxazoles: Synthesis of Combretastatin A‐4 analogues.
- Authors
Karetnikov, Georgy L.; Skvortsov, Dmitry A.; Lopatukhina, Elena V.; Nikolaeva, Svetlana N.; Bondarenko, Oksana B.
- Abstract
A new two‐stage regioselective access to non‐symmetric 3,5‐diarylisoxazoles starting from readily available 2‐aryl‐1,1‐dibromocyclopropanes is developed. The strategy based on the nitrosation/Suzuki arylation sequence ensures good yields of the products and a wide scope of substituents in both aryl rings. Using this strategy, a panel of combretastatin A‐4 (CA‐4) analogues presented by 3,5‐diarylisoxazole structural motif was synthesized and evaluated for their biological activity
- Subjects
NITROSATION; ARYLATION
- Publication
Asian Journal of Organic Chemistry, 2021, Vol 10, Issue 12, p3343
- ISSN
2193-5807
- Publication type
Article
- DOI
10.1002/ajoc.202100551