We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Or Is It Just a Little Relaxation?
- Authors
Govil, Yogesh K.; Katz, Philip O.
- Abstract
Lagergren <em>et al.</em> performed a population-based, case-control study to investigate the possible association between use of lower esophageal sphincter (LES)-relaxing medications and risk for adenocarcinoma of the esophagus, squamous cell cancer of the esophagus, and adenocarcinoma of the gastric cardia. They used randomly selected population-based controls from their population registry. The authors identified five groups of medications introduced before 1970 as LES relaxing: nitroglycerin, anticholinergics, β-adrenergic agonists, aminophylline, and benzodiazepines. They demonstrated an association, which they felt was causal, between the use of LES-relaxing medications and risk for adenocarcinoma of the esophagus. Long term use of LES-relaxing drugs correlated positively with the degree of esophageal adenocarcinoma risk, as demonstrated by an incidence rate ratio of 3.8 for esophageal adenocarcinoma in patients who used LES-relaxing drugs, particularly anticholinergics, daily for >5 yr. Importantly, they also found a higher prevalence of reflux among users of LES-relaxing agents. Cardia adenocarcinoma and esophageal squamous cell carcinoma were in general not associated with the use of these drugs, though a weaker association was noted with long term use of nitroglycerin and adenocarcinoma of the gastric cardia. No consistent association between use of LES-relaxing drugs and risk for esophageal squamous cell carcinoma was found.
- Subjects
ESOPHAGOGASTRIC junction; ESOPHAGEAL cancer; ADENOCARCINOMA; THERAPEUTIC use of nitroglycerin; PARASYMPATHOLYTIC agents; ADRENERGIC beta agonists; BENZODIAZEPINES; DRUG side effects; THERAPEUTICS
- Publication
American Journal of Gastroenterology (Springer Nature), 2001, Vol 96, Issue 5, p1638
- ISSN
0002-9270
- Publication type
Article
- DOI
10.1111/j.1572-0241.2001.03848.x