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- Title
A new clinical feature associated with familial early-onset of dystonic-guttural tics: An unusual diagnosis of PANDAS.
- Authors
Vitaliti, Giovanna; Trifiletti, Rosario R.; Falsaperla, Raffaele; Parano, Enrico; Spalice, Alberto; Pavone, Piero
- Abstract
Until today there is a large debate about the existence of PANDAS (pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections) or PANS (pediatric acute onset neuropsychiatric syndrome). These children usually have dramatic, "overnight" onset of symptoms, including motor or vocal tics, obsessions, and/or compulsions. In addition to these symptoms, children may also have comorbid features of associated disorders. Herein, we report a family with an early onset of tics, with exclusively dystonic and guttural tics. All patients had a particularly strong excitement trigger. Two of the patients were shown to have signs suggestive of PANDAS and all family members were Group A beta-hemolytic Streptococcus (GABHS) carriers. The PANDAS spectrum is probably a group of disorders. We have described a PANDAS variant, in which the family seems to share common autoimmune pattern and may be viewed in the large spectrum of PANDAS.
- Subjects
GENETICS of autoimmune diseases; AZITHROMYCIN; NEUROPSYCHOLOGY; STREPTOCOCCAL diseases; FAMILY history (Medicine); TIC disorders; DISEASE complications; GENETICS; THERAPEUTICS
- Publication
Journal of Pediatric Neurosciences, 2014, Vol 9, Issue 1, p79
- ISSN
1817-1745
- Publication type
Article
- DOI
10.4103/1817-1745.131497