We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Impaired specific CD8 T cell response with aging is not due to decreased expression of CD90 on TCR transgenic T cells.
- Authors
Jiu Jiang; Fisher, Erin; Murasko, Donna M
- Abstract
Background: CD90 (Thy-1) is a small glycoprotein that is particularly abundant on the surface of mouse thymocytes and peripheral T cells, and is often used as a marker in adoptive transfer experiments to distinguish donor and recipient T cells with different CD90 subtypes. We have performed adoptive transfer experiments with T cell receptor transgenic (TCR Tg) mice to study the impaired CD8 T cell response with aging. Findings: After stimulation with a CD8 T cell epitope, HA518-524, the response of TCR Tg CD8 T cells from aged mice was decreased compared to the response of TCR Tg T cells from young mice. CD90 expression was also substantially decreased on the TCR Tg CD8 T cells of aged mice. However, the responses of CD90hi and CD90low CD8 T cells of the aged mice were similar in both early activation and proliferation, demonstrating that the impaired Tg T cell response with aging is not associated with the altered CD90 expression on CD8 T cells. Conclusions: The impaired Tg CD8 T cell response in aged mice is not due to age-associated changes in CD90 expression on Tg CD8 T cells.
- Subjects
CD80 antigen; T cells; CD90 antigen; THYMOCYTES; CELL proliferation
- Publication
Immunity & Ageing, 2013, Vol 10, p1
- ISSN
1742-4933
- Publication type
Article
- DOI
10.1186/1742-4933-10-36