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- Title
Synthesis and stereochemistry of 6-membered ring phosphonates.
- Authors
Pungente, Michael D.; Weiler, Larry
- Abstract
Background: Organophosphorus compounds have important industrial and biomedical applications as pharmaceutical and agrochemical agents, as well as transition state analogs for the production of monoclonal antibodies. Methods: Two diastereomers of a 6-membered ring, cyclic phenyl phosphonate were synthesized in 8 steps from 1,3-butanediol. Results: The stereochemistry of the diastereomers was elucidated on the basis of 31P NMR signals, together with ¹H NMR nuclear Overhauser effects (NOE) difference experiments. Conclusions: Such cyclic phosphonates may have utility serving as transition state analogs for the production of monoclonal antibodies.
- Publication
QScience Connect, 2012, p1
- ISSN
2223-506X
- Publication type
Article
- DOI
10.5339/connect.2012.2