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- Title
Interrelationships Between Pituitary Hormones as Assessed From 24-hour Serum Concentrations in Healthy Older Subjects.
- Authors
van der Spoel, Evie; Roelfsema, Ferdinand; Akintola, Abimbola A; Jansen, Steffy W; Slagboom, P Eline; Westendorp, Rudi G J; Blauw, Gerard J; Pijl, Hanno; van Heemst, Diana
- Abstract
<bold>Context: </bold>Hormones of the hypothalamic-pituitary-target gland axes are mostly investigated separately, whereas the interplay between hormones might be as important as each separate hormonal axis.<bold>Objective: </bold>Our aim is to determine the interrelationships between GH, TSH, ACTH, and cortisol in healthy older individuals.<bold>Design: </bold>We made use of 24-hour hormone serum concentrations assessed with intervals of 10 minutes from 38 healthy older individuals with a mean age (SD) of 65.1 (5.1) years from the Leiden Longevity Study. Cross-correlation analyses were performed to assess the relative strength between 2 24-hour hormone serum concentration series for all possible time shifts. Cross-approximate entropy was used to assess pattern synchronicity between 2 24-hour hormone serum concentration series.<bold>Results: </bold>Within an interlinked hormonal axis, ACTH and cortisol were positively correlated with a mean (95% confidence interval) correlation coefficient of 0.78 (0.74-0.81) with cortisol following ACTH concentrations with a delay of 10 minutes. Between different hormonal axes, we observed a negative correlation coefficient between cortisol and TSH of -0.30 (-0.36 to -0.25) with TSH following cortisol concentrations with a delay of 170 minutes. Furthermore, a positive mean (95% confidence interval) correlation coefficient of 0.29 (0.22-0.37) was found between TSH and GH concentrations without any delay. Moreover, cross-approximate entropy analyses showed that GH and cortisol exhibit synchronous serum concentration patterns.<bold>Conclusions: </bold>This study demonstrates that interrelations between hormones from interlinked as well as different hypothalamic-pituitary-target gland axes are observed in healthy older individuals. More research is needed to determine the biological meaning and clinical consequences of these observations.
- Subjects
HYDROCORTISONE; THYROTROPIN; PITUITARY hormones; SERUM; INVERSE relationships (Mathematics); ADRENOCORTICOTROPIC hormone; STATISTICAL correlation; RESEARCH; RESEARCH methodology; CIRCADIAN rhythms; PROGNOSIS; EVALUATION research; MEDICAL cooperation; HUMAN growth hormone; COMPARATIVE studies; AGING; LONGEVITY; LONGITUDINAL method
- Publication
Journal of Clinical Endocrinology & Metabolism, 2019, pN.PAG
- ISSN
0021-972X
- Publication type
journal article
- DOI
10.1210/clinem/dgz253