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- Title
Serotonin biomarkers and brain-derived neurotrophic factors in heart failure: a prospective cohort.
- Authors
Guerra, Thaís de Rezende Bessa; Venâncio, Isabella Christina Lemos Diniz; Vieira, Soraya da Costa; Flores, Paula Vanessa Peclat; Cavalcanti, Ana Carla Dantas; Mesquita, Evandro Tinoco
- Abstract
Aim: To analyze the prognostic of serotonin biomarkers and brain-derived neurotrophic factors (BDNF) on depression in patients with systolic heart failure. Method: An observational, multicenter, prospective cohort study in three specialized centers, from April 2014 to November 2016. Study protocol: multidisciplinary medical consultation, depression inventory, quality of life questionnaire and blood test to measure serotonin and BDNF, with analysis via high performance liquid chromatography and ELISA, respectively. In order to study the association of these markers with the analytical methods used, a statistical evaluation will be carried out using the chi-square test and the Pearson correlation coefficient. For the analysis of mortality and hospitalization, logistic regression and analysis of mortality risk will be used. The statistical significance is 5%. Expected results: biological markers are more effective than conventional tests (questionnaires) when used to identify the degree of depression.
- Subjects
BRAZIL; MENTAL depression risk factors; ACADEMIC medical centers; BIOMARKERS; CHI-squared test; STATISTICAL correlation; ENZYME-linked immunosorbent assay; HEALTH care teams; CARDIAC patients; HEART failure; HIGH performance liquid chromatography; HOSPITAL care; OUTPATIENT services in hospitals; LONGITUDINAL method; MEDICAL cooperation; NERVE growth factor; PSYCHOLOGICAL tests; QUALITY of life; QUESTIONNAIRES; RESEARCH; SEROTONIN; T-test (Statistics); LOGISTIC regression analysis; SEVERITY of illness index; DATA analysis software; DESCRIPTIVE statistics; INFERENTIAL statistics; MANN Whitney U Test
- Publication
Online Brazilian Journal of Nursing, 2014, Vol 13, p395
- ISSN
1676-4285
- Publication type
Article