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- Title
Antimicrobial and Antiproliferative Potential of Anadenanthera colubrina (Vell.) Brenan.
- Authors
de Freitas Lima, Rennaly; Alves, Érika Ponchet; Rosalen, Pedro Luiz; Gois Ruiz, Ana Lúcia Tasca; Teixeira Duarte, Marta Cristina; Furletti Góes, Vivian Fernandes; Dantas de Medeiros, Ana Cláudia; Pereira, Jozinete Vieira; Godoy, Gustavo Pina; de Brito Costa, Edja Maria Melo
- Abstract
The aim of the present study was to perform an in vitro analysis of the antimicrobial and antiproliferative potential of an extract from Anadenanthera colubrina (Vell.) Brenan (angico) and chemically characterize the crude extract. Antimicrobial action was evaluated based on the minimum inhibitory concentration (MIC), minimum bactericidal/fungicidal concentration, and the inhibition of formation to oral biofilm. Cell morphology was determined through scanning electron microscopy (SEM). Six strains of tumor cells were used for the determination of antiproliferative potential. The extract demonstrated strong antifungal activity against Candida albicans ATCC 18804 (MIC = 0.031mg/mL), with similar activity found regarding the ethyl acetate fraction. The extract and active fraction also demonstrated the capacity to inhibit the formation of Candida albicans to oral biofilm after 48 hours, with median values equal to or greater than the control group, but the difference did not achieve statistical significance (P > 0.05). SEM revealed alterations in the cell morphology of the yeast. Regarding antiproliferative activity, the extract demonstrated cytostatic potential in all strains tested. The present findings suggest strong antifungal potential for Anadenanthera colubrina (Vell.) Brenan as well as a tendency toward diminishing the growth of human tumor cells.
- Subjects
BRAZIL; MEDICINAL plants; ALTERNATIVE medicine; ANTI-infective agents; ANTIFUNGAL agents; ANTINEOPLASTIC agents; BARK; BIOFILMS; BIOLOGICAL assay; BIOLOGICAL models; BONE marrow cancer; CANDIDA albicans; COLON tumors; DOSE-effect relationship in pharmacology; FLAVONOIDS; KIDNEY tumors; LUNG tumors; MICROBIAL sensitivity tests; MICROSCOPY; OVARIAN tumors; PROBABILITY theory; STATISTICS; PLANT extracts; DESCRIPTIVE statistics; IN vitro studies; PHARMACODYNAMICS
- Publication
Evidence-based Complementary & Alternative Medicine (eCAM), 2014, Vol 2014, p1
- ISSN
1741-427X
- Publication type
Article
- DOI
10.1155/2014/802696