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- Title
Extracts and Fractions from Edible Roots of Sechium edule (Jacq.) Sw. with Antihypertensive Activity.
- Authors
Lombardo-Earl, Galia; Roman-Ramos, Rubén; Zamilpa, Alejandro; Herrera-Ruiz, Maribel; Rosas-Salgado, Gabriela; Tortoriello, Jaime; Jiménez-Ferrer, Enrique
- Abstract
Sechium edule is traditionally used in Mexico as a therapeutic resource against renal diseases and to control high blood pressure. The purpose of this work is to evaluate the antihypertensive effect of the hydroalcoholic extract obtained fromthe roots of this plant, including its fractions and subfractions, on different hypertension models induced with angiotensin II (AG II). The hydroalcoholic extractwas tested on an in vitro study of isolated aorta rings denuded of endothelial cells, using AGII as the agonist; this assay proved the vasorelaxant effect of this extract. Vagotomized rats were administered different doses of AG II as well as the Hydroalcoholic extract, which reduced blood pressure in 30mmHg approximately; subsequently this extract was separated into two fractions (acetone and methanol) which were evaluated in the acute hypertension mouse model induced with AG II, where the acetone fraction was identified as the most effective one and was subsequently subfractioned using an open chromatographic column packed with silica gel. The subfractions were also evaluated in the acute hypertension model. Finally, the extract, fraction, and active subfraction were analyzed by MS-PDA-HPLC, identifying cinnamic derivative compounds like cinnamic acid methyl ester.
- Subjects
MEXICO; PHYTOTHERAPY; ANALYSIS of variance; ANIMAL experimentation; CHROMATOGRAPHIC analysis; HYPERTENSION; ANTIHYPERTENSIVE agents; MICE; RATS; RESEARCH funding; PLANT roots; VAGOTOMY; PLANT extracts; DATA analysis software; DESCRIPTIVE statistics; IN vitro studies
- Publication
Evidence-based Complementary & Alternative Medicine (eCAM), 2014, Vol 2014, p1
- ISSN
1741-427X
- Publication type
Article
- DOI
10.1155/2014/594326