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- Title
The Changes of Muscle FGF-6 Expression at Different Time Points after Exerciseinduced Muscle Damage.
- Authors
Yu, X.; Zuo, Q.; Chao, W.; Jiang, R.
- Abstract
Objective: To investigate the changes of fibroblast growth factor (FGF)-6 expression in the regeneration and repair process after exercise-induced muscle damage (EIMD) and the relationship with skeletal muscle regeneration and repair. Methods: The expression of FGF-6 at different time points was examined by reverse transcriptionpolymerase chain reaction (RT-PCR) and immunohistochemistry staining after a downhill treadmill exercise. Skeletal muscle injury and regeneration at different times after EIMD was assessed by haematoxylin and eosin (H&E) staining. Results: The FGF-6 protein expression was initially elevated, followed by a gradual reduction, while the changes of FGF-6 mRNA were almost all raised after the treadmill exercise. Conclusion: The results point out that FGF-6 is closely related to skeletal muscle regeneration and repair, probably implying a dual function in muscle regeneration.
- Subjects
FIBROBLAST growth factors; GENE expression; MUSCLE diseases; SKELETAL muscle; IMMUNOHISTOCHEMISTRY; PROTEIN expression
- Publication
West Indian Medical Journal, 2013, Vol 62, Issue 9, p793
- ISSN
0043-3144
- Publication type
Article