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- Title
The Effect of Serum Magnesium Levels and Serum Endothelin-1 Levels on Bone Mineral Density in Protein Energy Malnutrition.
- Authors
Ozturk, C. F.; Karakelleoglu, C.; Orbak, Z.; Yildiz, L.
- Abstract
An inadequate and imbalanced intake of protein and energy results in protein-energy malnutrition (PEM). It is known that bone mineral density and serum magnesium levels are low in malnourished children. However, the roles of serum magnesium and endothelin-1 (ET-1) levels in the pathophysiology of bone mineralization are obscure. Thus, the relationships between serum magnesium and ET- 1 levels and the changes in bone mineral density were investigated in this study. There was a total of 32 subjects, 25 of them had PEM and seven were controls. While mean serum ET-1 levels of the children with kwashiorkor and marasmus showed no statistically significant difference, mean serum ET-1 levels of both groups were significantly higher than that of the control group. Serum magnesium levels were lower than normal value in 9 (36%) of 25 malnourished children. Malnourished children included in this study were divided into two subgroups according to their serum magnesium levels. While mean serum ET-1 levels in the group with low magnesium levels were significantly higher than that of the group with normal magnesium levels (p < 0.05), mean bone mineral density and bone mineral content levels were significantly lower (p < 0.05). In conclusion, many factors play a role in the pathophysiology of changes in bone mineral density in malnutrition. Our study suggested that lower magnesium levels and higher ET-1 levels might be important factors in changes of bone mineral density in malnutrition. We recommend that the malnourished patients, especially with hypomagnesaemia, should be treated with magnesium early.
- Subjects
MALNUTRITION in children; PROTEIN-energy malnutrition; BONE density; PHYSIOLOGICAL effects of magnesium; ENDOTHELINS; PATHOLOGICAL physiology; KWASHIORKOR; MARASMUS
- Publication
West Indian Medical Journal, 2012, Vol 61, Issue 3, p213
- ISSN
0043-3144
- Publication type
Article
- DOI
10.7727/wimj.2011.164