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- Title
Determination of phthalates and their by-products in tissues of roach ( Rutilus rutilus) from the Orge river (France).
- Authors
Valton, A.; Serre-Dargnat, C.; Blanchard, M.; Alliot, F.; Chevreuil, M.; Teil, Marie
- Abstract
Seven phthalate by-products were investigated for the first time, in target tissues of roach from a contaminated river of the Ile-de-France district. All parent phthalates were bioaccumulated in liver and muscle and liver contents were correlated with river concentrations ( p < 0.01). All metabolites were found in liver, plasma and bile. The mono- iso-butyl phthalate (MiBP; 1.6 μg g dw of liver), followed by mono- n-butyl phthalate (MnBP; 1.5 μg g dw of liver) were the most abundant ones. Among the three metabolites of di-ethylhexyl phthalate (DEHP), mono (2-ethylhexyl) phthalate (MEHP) predominated in bile (15.5 ng ml) and liver (0.237 μg g dw), whereas in plasma, it was mono (2-ethyl-5-hydroxyhexyl) phthalate - MEHHP (214 ng ml). In liver, MEHP/DEHP ratios ranged from 0.04 to 0.2. Among the oxidized metabolites, only mono (2-ethyl-5-oxohexyl) phthalate (MEOHP) was correlated ( p < 0.05) with parent DEHP and appeared to be a more reliable marker of DEHP impact than the monoester.
- Subjects
ORGE River (France); PHTHALATE esters; WASTE products; ROACH (Fish); MARINE metabolites; DIETHYLHEXYL phthalate
- Publication
Environmental Science & Pollution Research, 2014, Vol 21, Issue 22, p12723
- ISSN
0944-1344
- Publication type
Article
- DOI
10.1007/s11356-014-3213-0