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- Title
Sleep-disordered breathing in children with Chiari malformation type II and myelomeningocele.
- Authors
Alsaadi, Muslim M.; Iqbal, Shaikh M.; Elgamal, Essam A.; Gozal, David
- Abstract
Background: The prevalence of sleep-disordered breathing (SDB) in children with Chiari malformation type II (CM-II), a known association of neural tube defects (NTD), has not been well documented. The aim of the present study was to assess the prevalence and possible predictive factors of SDB in patients with CM-II. Methods: The study included all patients with documented CM-II who were routinely referred from the Neurosurgery Clinic to the University Sleep Disorders Centre at King Khalid University Hospital, Riyadh, Saudi Arabia, between January 2002 and July 2009. Overnight full polysomnography (PSG) was performed in all patients. Polysomnographic data were analyzed using descriptive statistics. Results: Sixteen children (11 boys, five girls) were included in the study; their mean age was 4.7 years (range, 0.8-10 years) and their mean body mass index was 18.05 kg/m2 (range, 15.4-25.4 kg/m2). For the whole group, the mean apnea-hypopnea index (AHI) was 6.3/h (range, 0.2-24.5/h), with AHI recorded as >5/h in five patients (31.3%) and ≥10/h in three patients (18.8%). The mean central apnea-hypopnea index was 5.9/h (range, 0-24.5/h) and the mean obstructive apnea-hypopnea index was 0.4/h (range, 0-2.9/h). The mean arousal index was 15.1/h (range, 5-34/h). Conclusion: The major assumption linking CM-II and NTD with potential brainstem compression and respiratory dysfunction during sleep was confirmed. Indeed, SDB is highly prevalent, and clearly underreported and undertreated in patients with CM-II associated with NTD.
- Subjects
SAUDI Arabia; ACADEMIC medical centers; ARNOLD-Chiari deformity; SLEEP disorders; SPINA bifida; POLYSOMNOGRAPHY; BODY mass index; DISEASE prevalence; DATA analysis software; DESCRIPTIVE statistics; DISEASE complications; CHILDREN
- Publication
Pediatrics International, 2012, Vol 54, Issue 5, p623
- ISSN
1328-8067
- Publication type
Article
- DOI
10.1111/j.1442-200X.2012.03660.x