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- Title
Synthesis, characterisation and antimicrobial activity of (5-bromo-5-nitro-2-oxido-1,3,2-dioxaphosphinan-2-yl) amino acid esters.
- Authors
SANTHIPRIYA, PEMMASANI; RANI, CHINTHAPARTHI RADHA; REDDY, NANDANUR JAGANNADHA; SUNDAR, CHEREDDY SYAMA; REDDY, CIRANDUR SURESH
- Abstract
Synthesis of a new series of (5-bromo-5-nitro-2-oxido-1,3,2-dioxaphosphinan-2-yl)amino acid esters (3a-l) was accomplished via a two step process, which involves the prior preparation of the monochloride intermediate (2) and its subsequent reaction with the amino acid esters in dry tetrahydrofuran in the presence of triethylamine at reflux temperature. The title compounds (3a-l) structures were established by analytical, IR, ¹H-, 13C- and 31P-NMR, and mass spectral data. They exhibited significant antibacterial and antifungal activity.
- Subjects
ORGANIC synthesis; ANTI-infective agents; AMINO acids; ESTERS; CHEMICAL processes; CHLORIDES; INTERMEDIATES (Chemistry); TEMPERATURE effect; TETRAHYDROFURAN; ANTIFUNGAL agents; NITROPROPANE; NUCLEAR magnetic resonance spectroscopy
- Publication
Journal of the Serbian Chemical Society, 2011, Vol 76, Issue 5, p693
- ISSN
0352-5139
- Publication type
Article
- DOI
10.2298/JSC100520059S