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- Title
Adenovirus 36 infection and daycare starting age are associated with adiposity in children and adolescents.
- Authors
Lobor Cancelier, Ana Carolina; Dhurandhar, Nikhil V.; Peddibhotla, Swetha; Atkinson, Richard L.; Silva, Helena C. G.; Trevisol, Daisson J.; Schuelter-Trevisol, Fabiana
- Abstract
Objective: This study aimed to investigate human adenovirus 36 (Adv36) as an associated factor for adiposity in children and adolescents aged 9-12 years. Methods: This was a case-control study comparing overweight (cases) and eutrophic (controls) children and adolescents aged 9-12 years based on their body mass index in relation to human adenovirus 36 serology. Human adenovirus 36-specific neutralizing antibodies were assessed using the serum neutralization assay, and a questionnaire regarding the subjects' personal backgrounds, breastfeed history, age of starting daycare, and eating and exercise habits was also applied. Results: A total of 101 (51, eutrophic; 50, overweight) children were included in the study. The Adv36 seropositivity rate was of 15.8%, which increased the chance of being overweight by 3.17 times (p = 0.049). Enrollment in a full-time daycare center before the age of 24 months increased the chance of being overweight by 2.78 times (p = 0.027). Metabolic parameters (total cholesterol and blood glucose) were insignificantly different among children who were seropositive or seronegative for human adenovirus 36. Results: A total of 101 (51, eutrophic; 50, overweight) children were included in the study. The Adv36 seropositivity rate was of 15.8%, which increased the chance of being overweight by 3.17 times (p = 0.049). Enrollment in a full-time daycare center before the age of 24 months increased the chance of being overweight by 2.78 times (p = 0.027). Metabolic parameters (total cholesterol and blood glucose) were insignificantly different among children who were seropositive or seronegative for human adenovirus 36.
- Subjects
HUMAN adenoviruses; ADENOVIRUS diseases; OVERWEIGHT children; IMMUNOGLOBULINS; EXERCISE; FOOD habits; PHYSICAL activity
- Publication
Jornal de Pediatria, 2021, Vol 97, Issue 4, p420
- ISSN
0021-7557
- Publication type
Article
- DOI
10.1016/j.jped.2020.08.002