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- Title
Association Between the ACE I/D Gene Polymorphism and Physical Performance in a Homogeneous Non-Elite Cohort.
- Authors
Cam, F. Sirri; Colakoglu, Muzaffer; Sekuri, Cevad; Colakoglu, Sule; Sahan, Çagatay; Berdeli, Afig
- Abstract
Background: I/D polymorphism of the ACE gene may be associated with better endurance performance and a stronger response to exercise training. The aim of this study was to investigate the association between ACE gene polymorphism and athletic performance in a homogeneous cohort. Methods: Eighty-eight male non-elite Caucasian Turkish athletes with similar training backgrounds for at least for 6 months were studied for ACE gene polymorphisms by PCR analysis. Performance on the 60-meter sprint and middle-distance running tests were evaluated. Results: The distributions of the ACE I/D genotypes were 20.5%, 40.9%, and 38.6% for II, ID, and DD polymorphisms in the whole group (N = 88), respectively. The ACE DD genotype frequency was significantly higher in the superior group (56.7%) than in the poor (37.9%) and mediocre (20.7%) group in middle-distance running performance (c2 =11.778; p = 0.019). Conclusion: The ACE DD genotype may be related to better short-duration aerobic endurance performance. Larger homogeneous cohorts may help clarify
- Subjects
GENETIC polymorphisms; DNA; EXERCISE; ATHLETES; GENES
- Publication
Canadian Journal of Applied Physiology, 2005, Vol 30, Issue 1, p74
- ISSN
1066-7814
- Publication type
Article
- DOI
10.1139/h05-106