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- Title
A New Type of Chiral Sulfinamide Monophosphine Ligands: Stereodivergent Synthesis and Application in Enantioselective Gold(I)-Catalyzed Cycloaddition Reactions.
- Authors
Zhang, Zhan ‐ Ming; Chen, Peng; Li, Wenbo; Niu, Yanfei; Zhao, Xiao ‐ Li; Zhang, Junliang
- Abstract
A simple, new type of chiral sulfinamide monophosphines, the so-called Ming-Phos ligands, is reported; these ligands could be easily prepared from inexpensive and commercially available starting materials. The Ming-Phos ligands performed well in the enantioselective gold-catalyzed cycloaddition reaction of 2-(1-alkynyl)-alk-2-en-1-ones with nitrones. Both enantiomers of the products could be obtained in good yields and with excellent diastereo- and enantioselectivity through transformations that were catalyzed by gold complexes derived from two diastereomers of Ming-Phos ligand M5 (Ar=1-naphthyl).
- Subjects
SULFINAMIDES; LIGANDS (Chemistry); ENANTIOSELECTIVE catalysis; RING formation (Chemistry); NITRONES; DIASTEREOISOMERS
- Publication
Angewandte Chemie, 2014, Vol 126, Issue 17, p4439
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201401067