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- Title
The role of Aurora B expression in non-tumor liver tissues of patients with hepatocellular carcinoma.
- Authors
Tovuu, Lkhagva-Ochir; Utsunomiya, Tohru; Imura, Satoru; Morine, Yuji; Ikemoto, Tetsuya; Arakawa, Yusuke; Mori, Hiroki; Hanaoka, Jun; Kanamoto, Mami; Sugimoto, Koji; Saito, Yu; Yamada, Shinichiro; Asanoma, Michihito; Shimada, Mitsuo
- Abstract
Background: Aurora B is a serine-threonine kinase and chromosomal passenger protein involved in the control of chromosome assembly and segregation during mitosis. Aberrant expression of Aurora B has been reported in some tumors, including lung and hepatocellular carcinoma (HCC). We investigated the role of Aurora B expression in both HCC and matched adjacent non-tumor tissue. Methods: Sixty-three patients with HCC who underwent hepatic resection were enrolled in this study. Aurora B expression in tumor and non-tumor tissue was examined by use of quantitative reverse transcription-polymerase chain reaction. The patients were divided into high and low gene expression groups by median value, and clinicopathological data were compared between the two groups. Results: Aurora B expression was significantly higher in tumor tissue than in non-cancerous tissue ( P < 0.001). Disease-free survival was not significantly different between groups with high and low expression in the tumor tissues. For non-tumor tissues, disease-free survival of the low-expression group was significantly better than that of the high-expression group ( P < 0.05). The gene expression level of Aurora B correlated with results from liver function tests, for example prothrombin time. Conclusion: Aurora B expression in non-cancerous tissues may be a prognostic factor for HCC.
- Subjects
PROTEIN expression; LIVER physiology; LIVER cancer patients; SERINE/THREONINE kinases; CHROMOSOMAL proteins; MITOSIS
- Publication
International Journal of Clinical Oncology, 2014, Vol 19, Issue 4, p622
- ISSN
1341-9625
- Publication type
Article
- DOI
10.1007/s10147-013-0593-y