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- Title
Gastric small cell carcinoma with marked response to neoadjuvant chemotherapy.
- Authors
Nakamura, Yasuhiro; Otani, Setsuya; Otaka, Michiro; Shimada, Tomoyuki; Takahashi, Satsuki; Saito, Masahiro; Takahashi, Tohru; Komatsu, Masahumi; Suzuki, Toshie; Okubo, Shunji; Hayashi, Masato; Sasano, Hironobu
- Abstract
We report a patient with gastric small cell carcinoma (SCC) who showed a marked response to neoadjuvant chemotherapy. The patient was a 72-year-old Japanese man who was admitted because of epigastralgia. Subsequent examination revealed the presence of advanced gastric carcinoma in the lesser curvature of the lower body of the stomach, with multiple abdominal lymph node metastases. Endoscopic biopsy specimens from the tumor revealed SCC with moderately differentiated adenocarcinoma. The patient received neoadjuvant chemotherapy consisting of carboplatin (400 mg/m2, for 1 day), epirubicin (27 mg/m2, for 1 day), etoposide (70 mg/m2, for 3 days), and 5-fluorouracil (330 mg/m2, for 11 days). Clinically, the primary tumor and lymph node metastases were markedly reduced. Subsequently the patient underwent curative surgery and was alive without recurrence for more than 3 years after the surgery.
- Subjects
STOMACH cancer; GASTRIC mucosa; CANCER chemotherapy; METASTASIS; LYMPH nodes; ONCOLOGIC surgery
- Publication
International Journal of Clinical Oncology, 2005, Vol 10, Issue 5, p348
- ISSN
1341-9625
- Publication type
Article
- DOI
10.1007/s10147-005-0492-y