We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Role of dynamic MRI in the follow-up of acute Charcot foot in patients with diabetes mellitus.
- Authors
Zampa, Virna; Bargellini, Irene; Rizzo, Loredana; Turini, Francesca; Ortori, Simona; Piaggesi, Alberto; Bartolozzi, Carlo
- Abstract
<bold>Purpose: </bold>To evaluate the usefulness of magnetic resonance imaging (MRI) in assessing the level of activity of acute Charcot foot, monitoring treatment response and predicting healing time.<bold>Materials and Methods: </bold>Forty diabetic patients with acute Charcot foot were prospectively enrolled. Patients underwent limb immobilization and were followed every 3 months by clinical examination (skin temperature and circumferences) and MRI. MR protocol included T1-weighted and fast spin echo inversion recovery (FSE-IR) sequences, and a dynamic study (fast spoiled gradient echo), after gadolinium administration (0.1 ml/kg). The contrast medium uptake rate at D-MRI and the signal intensity (SI) ratio on the FSE-IR sequence were measured.<bold>Results: </bold>At baseline, mean contrast medium uptake rate was 136 ± 49.7% and the mean SI ratio was 5 ± 3. A high intra- and inter-observer agreement was found for the contrast medium uptake rate, whereas a low agreement was observed for the SI ratio. At 3 months' follow-up, reduction of the contrast medium uptake rate was observed in all patients with improved clinical findings (n = 34), whereas the SI ratio was reduced in 15/34 (44.1%) patients. Mean healing time was significantly related to the baseline contrast medium uptake rate (P=0.005); it was 5.3 ± 2.7 months in patients with contrast medium uptake rate ≤ 100%, compared with 9.1 ± 2.5 months in the remaining patients (P=0.0003).<bold>Conclusions: </bold>Contrast medium uptake rate obtained at D-MRI represents a reproducible parameter that is reliable for predicting and monitoring treatment outcome in acute Charcot foot.
- Subjects
MAGNETIC resonance imaging; CHARCOT joints; INTERMITTENT claudication; JOINT diseases; DIABETES; PEOPLE with diabetes; DISEASES; TREATMENT of diabetic foot; ANALYSIS of variance; CHI-squared test; LONGITUDINAL method; DIABETIC foot; CONTRAST media; ACUTE diseases; DIAGNOSIS; THERAPEUTICS
- Publication
Skeletal Radiology, 2011, Vol 40, Issue 8, p991
- ISSN
0364-2348
- Publication type
journal article
- DOI
10.1007/s00256-010-1092-0