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- Title
Improved oncologic outcomes by ablative radiotherapy in patients with bone metastasis from hepatocellular carcinoma.
- Authors
Kim, Tae Hyung; Park, Sangjoon; Rim, Chai Hong; Choi, Chiwhan; Seong, Jinsil
- Abstract
Purpose: For bone metastasis from hepatocellular carcinoma (HCC), radiotherapy (RT) has been used a palliative treatment with little impact on survival. Currently, ablative RT is popularly used, and a more than palliative effect is expected. Herein, we investigated the clinical efficacy of ablative RT in patients with bone metastasis from HCC. Methods: In total, 530 patients with 887 lesions treated in 1992–2019 were reviewed. Oligometastasis was defined as the presence of < 5 lesions. Total doses were normalized to obtain biologically effective doses (BEDs). The cut-off threshold of the BED was determined via receiver operating characteristics curve analysis. The Kaplan–Meier method was used to calculate overall survival (OS); propensity score matching (PSM) was performed to balance the heterogeneity in cases while comparing BEDs of ≥ 60 and < 60 Gy. Results: The most common site of metastasis was the spine (59%); 59 patients (11%) presented with oligometastasis, and 76.2% of patients showed objective pain palliation after RT. Median OS was 5.1 months for all patients; patients with oligometastasis showed longer OS than those without (9.8 vs. 4.7 months). A Cox proportional hazards model showed that performance status, Child–Pugh class, extraosseous metastasis, primary HCC status, α-fetoprotein level, and radiation dose (BED) were significant prognostic factors. Post PSM, BED was the only treatment-related prognostic factor that remained significant; the median OS durations were 8.1 and 4.4 months when the BEDs were ≥ 60 and < 60 Gy, respectively. Conclusion: Ablative RT improved OS and pain palliation in patients with bone metastasis from HCC.
- Subjects
HEPATOCELLULAR carcinoma; BONE metastasis; RECEIVER operating characteristic curves; PROPORTIONAL hazards models; OVERALL survival; PROGNOSIS
- Publication
Journal of Cancer Research & Clinical Oncology, 2021, Vol 147, Issue 9, p2693
- ISSN
0171-5216
- Publication type
Article
- DOI
10.1007/s00432-021-03553-2