We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Genetically Fusing Order‐Promoting and Thermoresponsive Building Blocks to Design Hybrid Biomaterials.
- Authors
Patkar, Sai S.; Wang, Bin; Mosquera, Ana Maria; Kiick, Kristi L.
- Abstract
The unique biophysical and biochemical properties of intrinsically disordered proteins (IDPs) and their recombinant derivatives, intrinsically disordered protein polymers (IDPPs) offer opportunities for producing multistimuli‐responsive materials; their sequence‐encoded disorder and tendency for phase separation facilitate the development of multifunctional materials. This review highlights the strategies for enhancing the structural diversity of elastin‐like polypeptides (ELPs) and resilin‐like polypeptides (RLPs), and their self‐assembled structures via genetic fusion to ordered motifs such as helical or beta sheet domains. In particular, this review describes approaches that harness the synergistic interplay between order‐promoting and thermoresponsive building blocks to design hybrid biomaterials, resulting in well‐structured, stimuli‐responsive supramolecular materials ordered on the nanoscale.
- Subjects
BLOCK designs; PHASE separation; POLYPEPTIDES; NANOSTRUCTURED materials; BIOMATERIALS; POLYMERS
- Publication
Chemistry - A European Journal, 2024, Vol 30, Issue 30, p1
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.202400582