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- Title
α‐Silylated Diazoalkynes: New Tools for Bioconjugation of Proteins.
- Authors
Zhao, Tuan; Sachon, Emmanuelle; Micouin, Laurent; Piccardi, Riccardo
- Abstract
α‐Silylated diazoalkynes are stabilized diazo compounds that can selectively react with carboxylic residues in buffered aqueous media. In‐situ fluoride induced desilylation increases this reactivity, leading to a very fast reaction. Application to the selective functionalization of RNase A, followed by post‐functionalization using click chemistry, is described. These new reagents expand the toolbox for native protein modification at carboxylic residues.
- Subjects
RIBONUCLEASE A; CLICK chemistry; DIAZO compounds; PROTEINS
- Publication
Chemistry - A European Journal, 2024, Vol 30, Issue 19, p1
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.202302807