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- Title
One‐Pot Double Oxidation Synthesis of N‐1‐Piperidonyl Amides From N‐1‐Piperidinyl Amides with meta‐Chloroperbenzoic Acid: Rimonabant Analogue as Model Study.
- Authors
Chen, Yu‐Chieh; Zeng, Wei‐Zheng; Li, Sin‐Min; Chou, Jia‐Yu; Tsai, Shuo‐En; Fuh Wong, Fung
- Abstract
A simple and efficient one‐pot oxidation synthesis of N‐1‐piperidonyl amides was successfully developed through the double oxidation of hydrazides (involving hydrazonium formation, azodioxy‐carbonyl compounds generation, and α‐carbon oxidation) by using meta‐chloroperbenzoic acid (mCPBA). The convenient oxidation method was also extended to Rimonabant analogue. The lactam oxidized Rimonabant analogue was first successfully synthesized for demonstrating the construction and characterized by NMR spectroscopic methods and the single‐crystal X‐ray diffraction study (ORTEP).
- Subjects
RIMONABANT; AMIDES; OXIDATION; X-ray diffraction; HYDRAZIDES; LACTAMS
- Publication
Chemistry - A European Journal, 2023, Vol 29, Issue 45, p1
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.202300702