We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Laser photocoagulation as treatment of non-exudative age-related macular degeneration: state-of-the-art and future perspectives.
- Authors
Querques, Giuseppe; Cicinelli, Maria Vittoria; Rabiolo, Alessandro; de Vitis, Luigi; Sacconi, Riccardo; Querques, Lea; Bandello, Francesco
- Abstract
Purpose: To give an updated review of laser approaches to non-exudative age-related macular degeneration (AMD). Methods: PubMed and Medline database searches were carried out using the terms 'laser' and 'photocoagulation' associated with 'age-related macular degeneration', and latest publications up to May 2017 have been reviewed. Moreover, the design of an ongoing single-center, non-randomized, phase I-II, pilot study, the PASCAL-GA trial, coordinated by F. Bandello, MD and G. Querques, MD from the IRCCS Ospedale San Raffaele, is described. Results: Either standard or subthreshold laser strategies have been tried to induce regression of distinct phenotypes of AMD, as reticular pseudodrusen (RPD), nascent geographic atrophy (nGA), and drusen-associated geographic atrophy (DAGA), with heterogeneous results. The aim of the PASCAL-GA protocol is to assess if subthreshold laser can restore the retinal pigment epithelium function in eyes with RPD and nGA offering a protective effect against extensive GA. Conclusions: New-generation medical and surgical approaches, including subthreshold laser photocoagulation, may have some success in downstaging AMD.
- Subjects
LASER photocoagulation; RETINAL degeneration; RANDOMIZED controlled trials; RHODOPSIN; RETINITIS pigmentosa
- Publication
Graefe's Archive of Clinical & Experimental Ophthalmology, 2018, Vol 256, Issue 1, p1
- ISSN
0721-832X
- Publication type
Article
- DOI
10.1007/s00417-017-3848-x