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- Title
Fluorescence spectral analysis of thioflavin T-γ-cyclodextrin interaction.
- Authors
Maskevich, A.; Kurhuzenkau, S.; Lickevich, A.
- Abstract
Fluorescence spectra and lifetimes of thioflavin T (ThT) in aqueous solutions of γ-cyclodextrin (γ-CD) were studied. Enhancements of the probe fluorescence intensity and lifetime were shown to result from the formation of two types (1:1 and 1:2) of ThT-γ-CD inclusion complexes. The formation constants of these complexes were determined based on spectral-kinetic measurements. Proof was provided that the probe did not form dimers at low concentrations (10-10 M).
- Subjects
FLUORESCENCE spectroscopy; THIOFLAVINS; CYCLODEXTRINS; AQUEOUS solutions; MOLECULAR probes; DIMERS
- Publication
Journal of Applied Spectroscopy, 2013, Vol 80, Issue 1, p36
- ISSN
0021-9037
- Publication type
Article
- DOI
10.1007/s10812-013-9717-4