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- Title
Ibalizumab: an anti-CD4 monoclonal antibody for the treatment of HIV-1 infection.
- Authors
Bruno, Christopher J.; Jacobson, Jeffrey M.
- Abstract
The majority of currently available agents for the treatment of HIV-1 infection act by targeting one of several intracellular steps in the viral life cycle. Despite improvements in efficacy and tolerability, the development of viral resistance to these agents is common and significant toxicity and adherence issues still occur. For this reason the development of safe, well tolerated antiviral agents that target a novel step in the viral life cycle remains important. Viral entry into host cells affords several potential extracellular targets for antiretroviral therapy. Ibalizumab, a humanized monoclonal antibody to CD4, the primary host cellular receptor for HIV-1 entry, has been shown to block HIV-1 entry in vitro. Early clinical trials have demonstrated significant antiviral efficacy with a >1 log10 reduction in viral load when given as monotherapy. Its long half-life, which allows weekly dosing, and its administration as an intravenous infusion differentiate it from other currently available antiretroviral agents. These properties may prove useful in allowing improved drug delivery to patients who have had difficulty adhering to daily oral regimens. Its unique mode of action reduces the risk of crossresistance with currently available antiretroviral agents, with the potential to expand the choices available to treat drug-resistant HIV-1.
- Subjects
THERAPEUTIC use of monoclonal antibodies; HIV infections; THERAPEUTICS; DRUG toxicity; ANTIVIRAL agents; RETROVIRUSES; ANTIRETROVIRAL agents
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 2010, Vol 65, Issue 9, p1839
- ISSN
0305-7453
- Publication type
Article
- DOI
10.1093/jac/dkq261