We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Comparative in vitro activity of ABT-773 and two macrolides against staphylococci.
- Authors
von Eiff, Christof; Peters, Georg
- Abstract
The anti-staphylococcal activity of ABT-773, a new member of the ketolides, was examined and compared with those of erythromycin and clarithromycin using the agar dilution method. A total of 336 well-defined clinical isolates of staphylococci, including a large number of clonally different methicillin-resistant strains with defined macrolide-lincosamide-streptogramin B (MLS(B)) resistance phenotypes were tested. The novel ketolide exhibited broad-spectrum anti-staphylococcal activity against both methicillin-susceptible and methicillin-resistant strains. Apart from strains with constitutive expression of MLS(B) resistance, all staphylococcal strains tested were inhibited by < or = 0.063 mg/L of ABT-773, irrespective of the resistance phenotype for methicillin.
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 2002, Vol 49, Issue 1, p189
- ISSN
0305-7453
- Publication type
journal article
- DOI
10.1093/jac/49.1.189