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- Title
SARS2020: an integrated platform for identification of novel coronavirus by a consensus sequence-function model.
- Authors
Zhang, Dachuan; Zhang, Tong; Liu, Sheng; Sun, Dandan; Ding, Shaozhen; Cheng, Xingxiang; Cai, Pengli; Ren, Ailin; Han, Mengying; Liu, Dongliang; Jia, Cancan; Gong, Linlin; Zhang, Rui; Xing, Huadong; Tu, Weizhong; Chen, Junni; Hu, Qian-Nan
- Abstract
Motivation The 2019 novel coronavirus outbreak has significantly affected global health and society. Thus, predicting biological function from pathogen sequence is crucial and urgently needed. However, little work has been conducted to identify viruses by the enzymes that they encode, and which are key to pathogen propagation. Results We built a comprehensive scientific resource, SARS2020, which integrates coronavirus-related research, genomic sequences and results of anti-viral drug trials. In addition, we built a consensus sequence-catalytic function model from which we identified the novel coronavirus as encoding the same proteinase as the severe acute respiratory syndrome virus. This data-driven sequence-based strategy will enable rapid identification of agents responsible for future epidemics. Availabilityand implementation SARS2020 is available at http://design.rxnfinder.org/sars2020/. Supplementary information Supplementary data are available at Bioinformatics online.
- Subjects
SARS-CoV-2; SARS virus; VIRUS-induced enzymes; COVID-19 pandemic; CLINICAL drug trials
- Publication
Bioinformatics, 2021, Vol 37, Issue 8, p1182
- ISSN
1367-4803
- Publication type
Article
- DOI
10.1093/bioinformatics/btaa767