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- Title
Synthesis of a Bioactive Composition of Chitosan–Selenium Nanoparticles.
- Authors
Apryatina, K. V.; Murach, E. I.; Amarantov, S. V.; Erlykina, E. I.; Veselov, V. S.; Smirnova, L. A.
- Abstract
A biologically active composition of chitosan-selenium nanoparticles has been developed. Selenium nanoparticles are characterized by a clear bimodal size distribution: 2–3 and ~37 nm. The main active centers of complexation with nanoparticles are the amino and hydroxyl groups of chitosan. In experiments on culturing fibroblasts of the hTERT BJ-5ta cell line on sample films, high biocompatibility of the composition was shown. It was shown that the composition of chitosan-selenium nanoparticles has a corrective effect on the oxidative processes of the body, reducing the activity of free-radical oxidation in the blood of animals. This opens up prospects for the use of this complex in the composition of antioxidant and adaptogenic drugs.
- Subjects
NANOPARTICLES; AMINO group; HYDROXYL group; CELL lines; SELENIUM
- Publication
Applied Biochemistry & Microbiology, 2022, Vol 58, Issue 2, p126
- ISSN
0003-6838
- Publication type
Article
- DOI
10.1134/S0003683822020028