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- Title
Chemistry: Easy bonding.
- Abstract
The article highlights a research that identifies a way of facilitating the production of drugs containing fluorine-carbon bonds. Tobias Ritter and his colleagues at Harvard University in Cambridge, Massachusetts, developed a palladium catalyst that can replace a boronic acid group on an aromatic ring with fluorine to make a fluorination reaction at room temperature. To make the catalyst resistant to attack from aggressive fluorination reagents, nitrogen-containing ligands were put in it. Carbon-fluorine bond forms in the last step without interruptions from the chemicals on the ring. The experiment is vital in position-emission tomography (PET) tracers because fluorine isotopes are short-lived.
- Subjects
UNITED States; FLUORINE; CARBON; FLUORINATION; CHEMICAL reactions; DRUG development; POSITRON emission tomography; INORGANIC compounds; RITTER, Tobias
- Publication
Nature, 2008, Vol 454, Issue 7203, p371
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/454371d