Presents a study on the localization of β-actin mRNA in migrating cells. Process on the transportation of the β-actin mRNA; Identification of a short nucleotide sequence that is necessary and sufficient to move β-actin mRNA to the protrusions of fibroblasts and other migrating cells; Capability of the migration behavior to be exploited in the cell culture to dissect the molecular mechanisms underlying the polarization and directed migration of cells.