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- Title
Cell signalling: NEMO keeps it straight.
- Authors
Cesari, Francesca
- Abstract
The article discusses the involvement of linear polyubiquitylation of Nuclear Factor-Kappa-B essential modulator (NEMO) in NF-Kappa-B activation. It references a study by F. Tokunaga et al in the January 11, 2009 issue of "Nature Cell Biology." It notes that the ubiquitin system modulates the function of proteins by conjugating different types of polyubiquitin chains. It also emphasizes that Lubac interacts with NEMO in immunoprecipitation assay in living organisms.
- Subjects
NF-kappa B; UBIQUITIN; DNA-binding proteins; MASS spectrometry; LIGASES
- Publication
Nature Reviews Molecular Cell Biology, 2009, Vol 10, Issue 3, p162
- ISSN
1471-0072
- Publication type
Article
- DOI
10.1038/nrm2638