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- Title
Calcium: Calcium signalling: dynamics, homeostasis and remodelling.
- Authors
Berridge, Michael J.; Bootman, Martin D.; Roderick, H. Llewelyn
- Abstract
Ca2+ is a highly versatile intracellular signal that operates over a wide temporal range to regulate many different cellular processes. An extensive Ca2+-signalling toolkit is used to assemble signalling systems with very different spatial and temporal dynamics. Rapid highly localized Ca2+ spikes regulate fast responses, whereas slower responses are controlled by repetitive global Ca2+ transients or intracellular Ca2+ waves. Ca2+ has a direct role in controlling the expression patterns of its signalling systems that are constantly being remodelled in both health and disease.
- Subjects
CALCIUM; HOMEOSTASIS; CELLS; EXOCYTOSIS; THROMBIN
- Publication
Nature Reviews Molecular Cell Biology, 2003, Vol 4, Issue 7, p517
- ISSN
1471-0072
- Publication type
Article
- DOI
10.1038/nrm1155