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- Title
EVALUATION OF THERAPEUTIC POTENTIAL OF CANNABIDIOLBASED PRODUCTS IN ANIMAL MODELS OF EPILEPTIC SEIZURES, NEUROPATHIC PAIN AND CHRONIC INFLAMMATION.
- Authors
BLEBEA, NICOLETA MIRELA; MIHAI, DRAGOȘ PAUL; ANDREI, CORINA; STOICA, DORA MIHAELA; CHIRIȚĂ, CORNEL; NEGREŞ, SIMONA
- Abstract
Cannabidiol (CBD) is one of the main cannabinoids (CBi) found in Cannabis species. The purpose of this study is to present the evaluation of the anticonvulsant effect in an animal model of epileptic seizures induced by the administration of electric shocks to mice for acute treatment with 3 vegetable oils with CBD. We also evaluated the antihyperalgic effect in a neuropathy model, and anti-inflammatory and analgesic potential of the CBD-containing emulsion after local administration. Significant anticonvulsant and antihyperlagic effects were observed for CBD-containing oils.
- Subjects
ANIMAL products; NEURALGIA; CHRONIC pain; ANIMAL models in research; VEGETABLE oils; EPILEPSY
- Publication
Farmacia, 2022, Vol 70, Issue 6, p1185
- ISSN
0014-8237
- Publication type
Article
- DOI
10.31925/farmacia.2022.6.24