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- Title
Ovarian Hyperstimulation Syndrome: A Review of Clinical Feature, Pathophysiology, Risk Factors, And Prevention.
- Authors
Ali, Rihab Abbas; Mukheef, Maher Abbood; Majeed, Hind Hadi
- Abstract
Ovarian hyperstimulation syndrome is a dangerous complication of ovulation induction during infertility treatment by gonadotropins stimulation and human chorionic gonadotropin injection. Increased capillary permeability, causing fluid leakage from the intravascular compartment, with the accumulation of fluid in the third-space and consequent intravascular dehydration, is the main change in the pathophysiology of ovarian hyperstimulation syndrome. Vascular endothelial growth factor is the main mediator in the development of ovarian hyperstimulation syndrome. The recent application of new modalities: Gonadotropin-releasing hormone antagonist protocol, Gonadotropin-releasing hormone agonist triggering of ovulation and embryo/oocyte vitrification, facilitates the elimination of ovarian hyperstimulation syndrome associated with controlled control ovarian hyperstimulation for IVF program. In this manuscript, we reviewed the pathophysiology, clinical features, predisposing factors, and both primary and secondary arrangement for preventing ovarian hyperstimulation syndrome as there is no single measure to prevent OHSS totally. Therefore, categorizing the women based on their risk potentiality seems to be beneficial to direct the line of management as early as possible to avoid the emergence of ovarian hyperstimulation syndrome.
- Subjects
OVARIAN hyperstimulation syndrome; INDUCED ovulation; VASCULAR endothelial growth factors; DEHYDRATION; GONADOTROPIN releasing hormone; PATHOLOGICAL physiology
- Publication
Kerbala Jorunal of Medicine, 2021, Vol 14, Issue 2, p2513
- ISSN
1990-5483
- Publication type
Article