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- Title
Correlation between Clinical Manifestations for Patients with Lupus Nephritis and Pathological Activity or Chronicity Indices.
- Authors
Al-Saegh, Riyadh Muhi; Matrood, Aqeel Abbas
- Abstract
Background: Systemic lupus erythematosus is a disorder of the immune system with many clinical manifestations. Aims of this study: is to find the correlations between the clinical manifestations of lupus nephritis and the pathological activity and chronicity indices. Patients and methods: This is a random cross-sectional study that took a period of two years started from 2015 to 2017, we collected kidney biopsy specimens from thirty patients with systemic lupus erythematosus, 28 were females and 2 were males. All patients were diagnosed as systemic lupus erythematosus if fulfilled =4 American college of rheumatology criteria for systemic lupus erythematosus. The activity and chronicity scoring indices are based on the percentage of glomeruli with each feature in the biopsy on a 0 to 3 scale, with a score of 0 = not present, 1 = <25% glomeruli, 2 = 25-50% glomeruli, and 3 indicating >50% glomeruli. Results: the chronicity index score increased with disease duration. The incidence of anemia increases with presence of high scores of chronicity index. With more than 40 percent of patients with lupus nephritis have glomeruli fibrosis percentage between 25-50%. Malar rash has significant correlation with both activity and chronicity indices. Conclusion: There was no significant correlation between gender, arthritis, edema, with both activity and chronicity indices.
- Subjects
LUPUS nephritis; SYSTEMIC lupus erythematosus; RENAL biopsy; IMMUNOLOGIC diseases; DISEASE duration
- Publication
Kerbala Jorunal of Medicine, 2020, Vol 13, Issue 1, p2260
- ISSN
1990-5483
- Publication type
Article