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- Title
In vivo imaging reveals a synchronized correlation among neurotransmitter dynamics during propofol and sevoflurane anesthesia.
- Authors
Gao-Lin Qiu; Li-Jun Peng; Peng Wang; Zhi-Lai Yang; Ji-Qian Zhang; Hu Liu; Xiao-Na Zhu; Jin Rao; Xue-Sheng Liu
- Abstract
General anesthesia is widely applied in clinical practice. However, the precise mechanism of loss of consciousness induced by general anesthetics remains unknown. Here, we measured the dynamics of five neurotransmitters, including γ-aminobutyric acid, glutamate, norepinephrine, acetylcholine, and dopamine, in the medial prefrontal cortex and primary visual cortex of C57BL/6 mice through in vivo fiber photometry and genetically encoded neurotransmitter sensors under anesthesia to reveal the mechanism of general anesthesia from a neurotransmitter perspective. Results revealed that the concentrations of γ-aminobutyric acid, glutamate, norepinephrine, and acetylcholine increased in the cortex during propofo-linduced loss of consciousness. Dopamine levels did not change following the hypnotic dose of propofol but increased significantly following surgical doses of propofol anesthesia. Notably, the concentrations of the five neurotransmitters generally decreased during sevoflurane-induced loss of consciousness. Furthermore, the neurotransmitter dynamic networks were not synchronized in the non-anesthesia groups but were highly synchronized in the anesthetic groups. These findings suggest that neurotransmitter dynamic network synchronization may cause anesthetic-induced loss of consciousness.
- Subjects
INTRAVENOUS anesthetics; LOSS of consciousness; PROPOFOL; VISUAL cortex; DOPAMINE; ANESTHESIA; PREFRONTAL cortex
- Publication
Zoological Research, 2024, Vol 45, Issue 3, p679
- ISSN
2095-8137
- Publication type
Article
- DOI
10.24272/j.issn.2095-8137.2023.302