We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
MRI-based R2* mapping in patients with suspected or known iron overload.
- Authors
Aslan, Emre; Luo, Jack W.; Lesage, An; Paquin, Philippe; Cerny, Milena; Chin, Anne Shu-Lei; Olivié, Damien; Gilbert, Guillaume; Soulières, Denis; Tang, An
- Abstract
Purpose: R2* relaxometry is a quantitative method for assessment of iron overload. The purpose is to analyze the cross-sectional relationships between R2* in organs across patients with primary and secondary iron overload. Secondary analyses were conducted to analyze R2* according to treatment regimen. Methods: This is a retrospective, cross-sectional, institutional review board-approved study of eighty-one adult patients with known or suspected iron overload. R2* was measured by segmenting the liver, spleen, bone marrow, pancreas, renal cortex, renal medulla, and myocardium using breath-hold multi-echo gradient-recalled echo imaging at 1.5 T. Phlebotomy, transfusion, and chelation therapy were documented. Analyses included correlation, Kruskal–Wallis, and post hoc Dunn tests. p < 0.01 was considered significant. Results: Correlations between liver R2* and that of the spleen, bone marrow, pancreas, and heart were respectively 0.49, 0.33, 0.27, and 0.34. R2* differed between patients with primary and secondary overload in the liver (p < 0.001), spleen (p < 0.001), bone marrow (p < 0.01), renal cortex (p < 0.001), and renal medulla (p < 0.001). Liver, spleen, and bone marrow R2* were higher in thalassemia than in hereditary hemochromatosis (all p < 0.01). Renal cortex R2* was higher in sickle cell disease than in hereditary hemochromatosis (p < 0.001) and in thalassemia (p < 0.001). Overall, there was a trend toward lower liver R2* in patients assigned to phlebotomy and higher liver R2* in patients assigned to transfusion and chelation therapy. Conclusion: R2* relaxometry revealed differences in degree or distribution of iron overload between organs, underlying etiologies, and treatment.
- Subjects
KIDNEY cortex; SICKLE cell anemia; BONE marrow; SPLEEN; PANCREAS; IRON overload
- Publication
Abdominal Radiology, 2021, Vol 46, Issue 6, p2505
- ISSN
2366-004X
- Publication type
Article
- DOI
10.1007/s00261-020-02912-w