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- Title
Aging is not associated with bone marrow-resident progenitor cell depletion.
- Authors
Povsic TJ; Zhou J; Adams SD; Bolognesi MP; Attarian DE; Peterson ED; Povsic, Thomas J; Zhou, Jiying; Adams, Stacie D; Bolognesi, Michael P; Attarian, David E; Peterson, Eric D
- Abstract
Changes in progenitor cell biology remain at the forefront of many theories of biologic aging, but there are limited studies evaluating this in humans. Aging has been associated with a progressive depletion of circulating progenitor cells, but age-related bone marrow-resident progenitor cell depletion has not been systematically determined in humans. Patients undergoing total hip replacement were consented, and bone marrow and peripheral progenitor cells were enumerated based on aldehyde dehydrogenase activity and CD34 and CD133 expression. Circulating progenitors demonstrated an age-dependent decline. In contrast, marrow-resident progenitor cell content demonstrated no age association with any progenitor cell subtype. In humans, aging is associated with depletion of circulating, but not marrow-resident, progenitors. This finding has impact on the mechanism(s) responsible for age-related changes in circulating stem cells and important implications for the use of autologous marrow for the treatment of age-related diseases.
- Publication
Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2010, Vol 65A, Issue 10, p1042
- ISSN
1079-5006
- Publication type
journal article
- DOI
10.1093/gerona/glq110