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- Title
AChRAb and MuSKAb double-seropositive myasthenia gravis: a distinct subtype?
- Authors
Zhang, Jieni; Chen, Yin; Chen, Jiaxin; Huang, Xin; Wang, Haiyan; Li, Yan; Liu, Weibin; Feng, Huiyu
- Abstract
Introduction: This study investigated the characteristics of double-seropositive myasthenia gravis (DSP-MG) in southern China for disease subtype classification. Methods: A case-control study was carried out in which the characteristics of DSP-MG patients (n = 17) were compared to those of muscle-specific tyrosine kinase antibody-positive (MuSK)-MG and acetylcholine receptor antibody-positive (AChR)-MG patients (n = 8 and 27, respectively). We also performed a literature review of DSP-MG patients. Results: Compared to AChR-MG, DSP-MG had greater bulbar dysfunction (47.1% vs 18.6%, P = 0.04), higher incidence of myasthenia crisis (41.2% vs 14.8%, P = 0.04), more severe Myasthenia Gravis Foundation of America classification at maximum worsening, greater autoantibody abnormalities (70.6% vs 33.3%, P = 0.015), greater need for immunosuppressant treatment (58.8% vs 3.7%, P < 0.001), and worse prognosis with less remission (11.8% vs 55.6%, P = 0.001). There were no differences between DSP-MG and MuSK-MG patients. DSP-MG described in published reports was comparable to MuSK-MG. Discussion: DSP-MG in southern China may be a subtype of MuSK-MG.
- Subjects
AMERICA; CHINA; MYASTHENIA gravis; PROTEIN-tyrosine kinases; CHOLINERGIC receptors; MUSCLE weakness; NOSOLOGY; CASE-control method
- Publication
Neurological Sciences, 2021, Vol 42, Issue 3, p863
- ISSN
1590-1874
- Publication type
Article
- DOI
10.1007/s10072-021-05042-3