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- Title
Parkinson's disease: oxidative stress and therapeutic approaches.
- Authors
Surendran S; Rajasankar S; Surendran, Sankar; Rajasankar, Srinivasagam
- Abstract
Parkinson's disease (PD) is a neurodegenerative disorder, caused by reduced levels of catecholamines and oxidative stress. Symptoms seen in the disease include tremor, rigidity, bradykinesia and postural disability. Oxidative stress plays a key role in neurodegeneration and motor abnormalities seen in PD. Altered levels of the protein caused by these changes lead to defective ubiquitin-proteasome pathway. Neurodegeneration seen in PD and Canavan disease has a common mechanism. Recent studies suggest that herbal medicines can improve molecular changes and motor functions seen in PD.
- Publication
Neurological Sciences, 2010, Vol 31, Issue 5, p531
- ISSN
1590-1874
- Publication type
journal article
- DOI
10.1007/s10072-010-0245-1