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- Title
Serum Vitamin D Concentrations Among Pregnant Women and Its Influence on the Fetal Anthropometric Measurements.
- Authors
Yıldırım, Melahat; Desdicioğlu, Raziye; İpek, Ali; Kara, Halil; Dauletkazin, Gülcan; Yavuz Avşar, Ayşe Filiz
- Abstract
Objectives: Vitamin D is a fat-soluble vitamin which comes primarily from exposure to sunlight. Vitamin D deficiency (VDD) in pregnancy is found to be related to adverse pregnancy outcomes including preeclampsia, hypertension, caesarean section, preterm birth, etc. In this current study, we aimed to evaluate the relationship between VDD and fetal anthropometric measurements, amniotic fluid abnormalities, and placental location in pregnant women with singleton pregnancies. Materials and Methods: This prospective study consisted of 268 pregnant women who attended to the antenatal clinics for their routine second trimester prenatal ultrasound screening. VDD is defined as <30 nmol/L (equals to 12 ng/ml) based on the criteria regarding the vitamin D status. Study population was subdivided into two groups with respect to their serum 25(OH)D levels: Group 1 - VDD group (n= 190); 25(OH)D <12 ng/ml, and Group 2 - normal vitamin D (NVD) group (n= 78); 25(OH)D ≥12 ng/ml. Fetal anthropometric measurements, placental location, and amniotic fluid abnormalities were compared between groups. A p-value < 0.05 was considered statistically significant. Results: The mean vitamin D was 7 .52±2.26 ng/ml in VDD g roup, and 22.61±19.40 ng/ml in NVD group (p=0.001). There were no differences in the measurements of fetal biparietal diameter, femur length, abdominal circumference, cisterna magna, lateral ventricles and transverse cerebellar diameter between groups (p> 0.05). Fifty five % of women in VDD group and 46.6% of the cases in NVD group had their placenta located in corpus posterior of the uterus (p= 0.145). Ten out of 190 women in VDD group and 7 out of 78 women in NVD group had polyhydramnios in the study (p= 0.457). Conclusion: The current study failed to demonstrate the relationship between VDD and fetal anthropometric measurements, amniotic fluid abnormalities, and placental location in pregnant women at 20-25 weeks of gestation. Based on the findings in literature, we can assume that other protective mechanisms may play role in preventing fetus from the influence of VDD during the second trimester or fetus has not been affected from the disease, because fetus does not require much calcium and vitamin D due to its small bone mass during this period. The adverse impact of VDD on the fetal bone development can be prevented by appropriate treatment in pregnancy.
- Subjects
VITAMIN D deficiency; FETAL development; PREGNANCY complications; ANTHROPOMETRY; PLACENTA
- Publication
Ankara Medical Journal, 2016, Vol 16, Issue 2, p142
- ISSN
2148-4570
- Publication type
Article
- DOI
10.17098/amj.7218