We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Complete Biochemical Remission With Oral Vancomycin in a Patient With Primary Sclerosing Cholangitis and High Serum Immunoglobulin G4 Levels.
- Authors
Sohal, Aalam; Kowdley, Kris V.
- Abstract
Primary sclerosing cholangitis (PSC) is a progressive cholestatic liver disease characterized by intrahepatic and extrahepatic bile duct strictures leading to cirrhosis. A subtype with elevated serum immunoglobulin (Ig) G4 levels has been recently identified. Elevated IgG4 titers can be present in 9%-15% of patients with PSC. Currently, liver transplantation is the only effective treatment of PSC, although multiple medical therapies are under evaluation. We report a case of a young adult with PSC and elevated IgG4 levels who had marked serum aminotransferase elevation; the patient had an incomplete response to steroids but achieved complete biochemical remission after initiation of oral vancomycin.
- Subjects
IMMUNOGLOBULINS; ORAL drug administration; ENDOSCOPIC retrograde cholangiopancreatography; VANCOMYCIN; MAGNETIC resonance imaging; BILE duct diseases; TREATMENT effectiveness; ABDOMINAL pain; PREDNISONE
- Publication
ACG Case Reports Journal, 2024, Vol 11, Issue 1, p1
- ISSN
2326-3253
- Publication type
Article
- DOI
10.14309/crj.0000000000001256