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- Title
Prognostic factors in a non-metastatic breast cancer cohort using RMST function: a single-institution experience.
- Authors
Niță, Irina; Nițipir, Cornelia; Bădărău, Ioana Anca
- Abstract
Background and aim. Our aim is to examine the relationship between several factors (such as personal, tumoral or therapeutic) and the outcome of the patients. We analyzed a cohort of patients with early and locally advanced breast cancer (BC) using the restricted mean survival time (RMST). This value summarizes the treatment efficacy in terms of eventfree time over a fixed period. Materials and method. We evaluated the prognostic values in 143 patients treated for early BC at the “Elias” University Emergency Hospital, Bucharest, Romania, and followedup for a maximum of 36 months. The protocol was amended to include the personal factors, the levels of education and background, the clinical stage, the tumor aspects (grading, histology type or immunohistochemistry characteristics) and some aspects related to the treatment received. The methodology consisted of KaplanMeier analysis and RMST for the entire sample. The main endpoints of the study were overall survival (OS) and progressionfree survival (PFS). Using “backward selection”, we analyzed only the variables that were statistically significant and influenced the prognostic of the patients. Results. The levels of education impacted both RMST OS (35.30 versus 26.70) and death HR (hazard ratio) in the group of patients with low educational levels. The clinically staged lymph node influenced both OS (p=0.05) and PFS (p=0.0006) for the patients with palpable or imaging proof of lymph node involvement of station 2 or 3. Both lower Ki67 and low tumor grade were associated with better prognosis in terms of OS and PFS for our patients’ cohort. Conclusions. RMST provides an intuitive and explicit way to express the effect of risk factors on OS and PFS in a cohort of nonmetastatic BC patients. Independent predictors for the OS were the education level, with a 10.2fold HR increase, and triplenegative breast cancer (TNBC), with a 6fold HR increase, regardless of education level. Independent predictors for PFS were clinical tumor stage N2, N3, Ki67 value, high tumor grade and the basic level of CA153 marker.
- Subjects
BUCHAREST (Romania); BREAST cancer; SURVIVAL rate; PROGNOSIS; OVERALL survival; TRIPLE-negative breast cancer
- Publication
Oncolog-Hematolog, 2021, Issue 55, p44
- ISSN
2066-8716
- Publication type
Article